Affiliation:
1. Pathomorphology laboratory with histochemistry, N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare Department
Abstract
Summary. The use of endoscopic transsphenoidal access is an effective and safe method for the surgical treatment of pituitary adenomas (PA). In endoscopic transsphenoidal surgeries, there is a need to control intracranial pressure (ICP) for reposition and expansion of the tumor capsule. Currently, the main method for reducing ICP in transsphenoidal surgery is installation of an external lumbar drainage, which is associated with a number of complications.Aim of study. To improve the results of surgical treatment of patients with arterial hypertension using hypertonic saline solution.Material and methods. A clinical and anatomical analysis of material from 27 deceased patients who were treated in the cardiac surgery department of the Institute was carried out. Valve replacement was performed in 11 patients, aortic replacement - 2, valves and aorta - 7, combined operations - 7. The patient’s records, autopsy protocols, results of histological examination of surgical and autopsy material were studied. Already on the next day after surgery, an increase in serum creatinine by more than 25% was noted under the conditions of CBR. Morphological examination of the kidneys revealed acute pathological processes - necrosis of nephrocytes of the convoluted tubules in 59.3% of cases and dystrophic changes in 40.7% of cases against the background of chronic pathology (nephrosclerosis, vascular atherosclerosis, glomerulosclerosis, pyelonephritis, secondary contracted kidney). After coronary angiography with a radiopaque contrast agent (RCA), signs of excretory nephrosis were noted, often with fixation of the RCA in the loop of Henle, with tubulorexis and the formation of cell casts.
Publisher
The Scientific and Practical Society of Emergency Medicine Physicians
Reference9 articles.
1. Wang Y, Bellomo R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol. 2017;13(11):697–711. PMID: 2869251. https://doi.org/10.1038/nrneph.2017.119
2. Hu J, Chen R, Liu S, Yu X, Zou J, Ding X. Global Incidence and Outcomes of Adult Patients With Acute Kidney Injury After Cardiac Surgery: A Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. 2016; 30(1):82–89. PMID: 26482484. https://doi.org/10.1053/j.jvca.2015.06.017
3. Kellum JА, Lameire N. Kidney disease: improving global outcomes (KDIGO): clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:8–12.
4. Smirnov AV, Dobronravov VA, Rumyantsev ASh, Kayukov IG. Ostroe povrezhdenie pochek. Moscow: Meditsinskoe informatsionnoe agentstvo Publ.; 2015. (In Russ.)
5. Sokolov DV, Polushin YuS. Acute Renal Injury in the Peri-Operative Period. Messenger of Anesthesiology and Resuscitation. 2018;15(1):46–54. (In Russ.) https://doi.org/10.21292/2078-5658-2018-15-1-46-54
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献