Comparative Analysis of Antibiofilm Properties of Fluorescein Derivatives Over Commercial Antibiotics
Author:
Yeshwanth S.S.,Sivaprasad S.
Abstract
Aim: The study is about to compare the antibiofilm properties of Novel Fluorescein derivatives to those of commercial antibiotics, using docking to see how the ligand, protein, and antibiotic interact molecularly. Materials and methods: The 3D structures of protein and ligands were procured from the PubChem, Drug bank, and PDB databases. The sample size was calculated using G power with pretest power at 80% and alpha value of 0.05. The sample size per group is 10 and total sample size is 30. Docking studies of protein and ligands were performed using Auto dock software. Statistics of the interactions were analyzed using IBM SPSS software. Result: Protein ligand interactions revealed that fluorescein shows more binding affinity towards the protein compared to commercial antibiotics cephalexin and cephalexin monohydrate. The binding affinity values were compared using SPSS software, which reveals that the statistical insignificance observed between the fluorescein and antibiotics cephalexin and cephalexin monohydrate is 0.519 and 0.400 respectively. Conclusion: The fluorescein ligand appears to be more specific and selectively works against the target protein when compared to the antibiotics.
Subject
General Medicine,Materials Chemistry,General Medicine,General Medicine,General Materials Science,General Medicine,General Medicine,Aerospace Engineering,General Medicine