Oxidative stress and one carbon metabolism in prostate neoplasm

Abstract

Carcinoma of the prostate is the most common malignant tumour in men over the age of 65 years with peak age of incidence between 70 and 74 years. Oxidative stress and one carbon metabolism are important contributary factors in etiopathogenesis in Prostate Neoplasm. Significant increase in oxidative stress and serum homocysteine level and no difference of serum vitamin B12 was found in BPH and prostate cancer cases compared to control group. Following review compare level of Oxidative Stress Marker and One Carbon Metabolism markers between Prostate neoplasm patients and control Group. Antioxidant drugs may play a role in influencing outcome in these patients. However, randomized trials are required to investigate.