Present-day tendencies in accompanying therapy in cancer treatment: from theory of adaptational reactions to bio-information technologies translation

Abstract

At present, to develop new, scientifically justified, technologiesof an accompanying therapy to improve the oncological situationis a challenge to health care. A therapy to accompany aspecific cancer treatment in case of a malignant process in anorganism is dictated by the necessity to raise the nonspecific resistanceof the organism in cancer patients. In this case, originalmethodological approaches to initiate the mechanisms of thenonspecific resistance have been developed on the basis of thetheory of the adaptational reactions. Within the framework ofthe above theory, some concepts of relationship between thespecific and nonspecific anti-tumor processes have been extensivelydeveloped that may be successfully applied to solvingtasks of the National Health Care Program.Aim. The aim hereof is to introduce the theoretical basics ofthe nonspecific adaptation regulation and control by a tumor-bearing organism into practice for an integrated treatmentof malignant tumors with the use of the activation therapy technologies.Materials and methods. Our research work has involvedclinical data on 1310 patients, who have been diagnosedwith cancer of different localization: breast cancer (n = 170),cervical cancer (n = 60), lung cancer (n = 760), bladder cancer(n = 120), brain gliomas of high grade of malignancy andmetastatic damage (n = 170) and extended colorectal cancer(n = 30) and who have completed their treatment at the NationalMedical Research Centre of Oncology of the Ministry ofHealth of the Russian Federation.