1. Cardiovascular Research Group (R.Y., M.F., R.A., Y.L., S.H., S.K., J.S., R.M., A.G., P.D., M.J., H.S.), Core Technologies Facility, University of Manchester, Manchester M13 9PT, United Kingdom
2. Cardiovascular Trials Unit (R.Y., M.F. S.K., J.S., H.S.), Manchester M13 9WL, United Kingdom
3. Department of Clinical Biochemistry (M.F., P.P.), Central Manchester University Hospitals, National Health Service Foundation Trust, Manchester M13 9WL, United Kingdom
4. Departments of Medicine (P.T., A.A.S.), United Kingdom
5. Surgery (B.A.), Salford M6 8HD, United Kingdom
6. the North West Diabetes Local Research Network (M.G.), Salford Royal National Health Service Foundation Trust, Salford M6 8HD, United Kingdom