Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly-Reference-Cited by-同舟云学术

Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly

Published:2013-06-01 Issue:6 Volume:98 Page:2604-2612
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Breen Leigh¹²,Stokes Keith A.³,Churchward-Venne Tyler A.¹,Moore Daniel R.¹,Baker Stephen K.⁴,Smith Kenneth⁵,Atherton Philip J.⁵,Phillips Stuart M.¹

Affiliation:

1. 1Department of Kinesiology (L.B., T.A.C.-V., D.R.M., S.M.P.), McMaster University, Hamilton, Ontario, Canada L8S 4K1

2. School of Sport and Exercise Sciences (L.B.), University of Birmingham, Birmingham B15 2TT, United Kingdom

3. Department for Health (K.A.S.), University of Bath, Bath BA2 7AY, United Kingdom

4. School of Medicine (Physical Medicine and Rehabilitation) (S.K.B.), McMaster University, Hamilton, Ontario, Canada L8S 4K1

5. School of Graduate Entry Medicine and Health (K.S., P.J.A.), Division of Clinical Physiology, University of Nottingham, Derby NG7 2RD, United Kingdom

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/98/6/2604/10425168/jcem2604.pdf

Reference39 articles.

1. Sarcopenia: origins and clinical relevance;Rosenberg;J Nutr,1997

2. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women;Yarasheski;Am J Physiol,1993

3. Myofibrillar protein synthesis in young and old men;Welle;Am J Physiol,1993

4. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle;Cuthbertson;FASEB J,2005

5. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly;Volpi;J Clin Endocrinol Metab,2000

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