Diminished 11β-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life

Author:

Rogers Samantha L.1,Hughes Beverly A.2,Jones Christopher A.1,Freedman Lauren1,Smart Katherine1,Taylor Norman3,Stewart Paul M.2,Shackleton Cedric H. L.24,Krone Nils P.2,Blissett Jacqueline1,Tomlinson Jeremy W.2

Affiliation:

1. School of Psychology (S.L.R., C.A.J., L.F., K.S., J.B.), Birmingham B15 2TH, United Kingdom

2. Centre for Endocrinology, Diabetes, and Metabolism (B.A.H., P.M.S., C.H.L.S., N.P.K., J.W.T.), Institute of Biomedical Research, School of Clinical and Experimental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TH, United Kingdom

3. Department of Clinical Biochemistry (N.T.), King's College Hospital National Health Service Foundation Trust, London WC2R 2LS, United Kingdom

4. Children's Hospital, Oakland's Research Institute (C.H.L.S.), Oakland, California 94609

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference56 articles.

1. Fetal programming and metabolic syndrome;Rinaudo;Annu Rev Physiol,2012

2. Adrenocortical activity in healthy children is associated with fat mass;Dimitriou;Am J Clin Nutr,2003

3. Cortisol metabolism in human obesity: impaired cortisone–>cortisol conversion in subjects with central adiposity;Stewart;J Clin Endocrinol Metab,1999

4. Impaired glucose tolerance and insulin resistance are associated with increased adipose 11β-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5α-reductase activity;Tomlinson;Diabetes,2008

5. Exogenous corticosteroids and in utero oxygenation modulate indices of fetal insulin secretion;Verhaeghe;J Clin Endocrinol Metab,2005

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