Does Somatostatin Have a Role in the Regulation of Cortisol Secretion in Primary Pigmented Nodular Adrenocortical Disease (PPNAD)? A Clinical and in Vitro Investigation

Author:

Bram Zakariae1,Xekouki Paraskevi1,Louiset Estelle1,Keil Meg F.2,Avgeropoulos Dimitrios3,Giatzakis Christoforos3,Nesterova Maria3,Sinaii Ninet4,Hofland Leo J.5,Cherqaoui Rabia3,Lefebvre Hervé16,Stratakis Constantine A.32

Affiliation:

1. INSERM Unité 982 (Z.B., E.L., H.L.), Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, 76821 Rouen, France

2. Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Pediatric Endocrinology Inter-Institute Training Program (M.F.K., C.A.S.), Bethesda, Maryland 20892

3. Section on Endocrinology and Genetics (P.X., D.A., C.G., M.N., R.C., C.A.S.), Bethesda, Maryland 20892

4. National Institute of Child Health and Human Development, National Institutes of Health, and Clinical Center (N.S.), National Institutes of Health, Bethesda, Maryland 20892

5. Erasmus Medical Center (L.J.H.), 3015 GE Rotterdam, The Netherlands

6. Department of Endocrinology (H.L.), Institute for Research and Innovation in Biomedicine, University Hospital of Rouen, 76031 Rouen, France

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference36 articles.

1. Expression of preprosomatostatin in heterologous cells: biosynthesis, posttranslational processing, and secretion of mature somatostatin;Warren;Cell,1984

2. Classification and nomenclature of somatostatin receptors;Hoyer;Trends Pharmacol Sci,1995

3. Opportunities in somatostatin research: biological, chemical and therapeutic aspects;Weckbecker;Nat Rev Drug Discov,2003

4. Molecular and pharmacological characterization of somatostatin receptor subtypes in adrenal, extraadrenal, and malignant pheochromocytomas;Epelbaum;J Clin Endocrinol Metab,1995

5. Differential expression of the human somatostatin receptor subtypes sst1 to sst5 in various adrenal tumors and normal adrenal gland;Ueberberg;Horm Metab Res,2005

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