Hypermethylation of a New Distal Sodium/Iodide Symporter (NIS) Enhancer (NDE) Is Associated With ReducedNISExpression in Thyroid Tumors

Author:

Galrão Ana Luiza1,Camargo Rosalinda Y.1,Friguglietti Celso U.2,Moraes Lais3,Cerutti Janete Maria3,Serrano-Nascimento Caroline4,Suzuki Miriam F.5,Medeiros-Neto Geraldo1,Rubio Ileana G. S.6

Affiliation:

1. Thyroid Unit (A.L.G., R.Y.C., G.M.-N.), Cellular and Molecular Endocrine Laboratory, LIM-25, University of São Paulo Medical School (FM-USP), 01246-903 São Paulo, Brazil;

2. Head and Neck Surgery of Santa Catarina Hospital (C.U.F.), 01310-000 São Paulo, Brazil;

3. Genetic Bases of Thyroid Tumors Laboratory (L.M., J.M.C.), Division of Genetics, Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), 04039-032 São Paulo, Brazil;

4. Department of Physiology and Biophysics (C.S.-N.), Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brazil;

5. Center of Biotechnology (M.F.S.), Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, 05508–000 São Paulo, Brazil;

6. Department of Biological Sciences (I.G.S.R.), UNIFESP, 09972-270 São Paulo, Brazil

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. National Cancer Institute. Thyroid cancer. http://www.cancer.gov/cancertopics/types/thyroid.

2. Pathogenetic mechanisms in thyroid follicular-cell neoplasia;Kondo;Nat Rev Cancer,2006

3. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1;Ricarte-Filho;Cancer Res,2009

4. RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults;Elisei;J Clin Endocrinol Metab,2001

5. Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells;Mitsutake;Cancer Res,2005

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