The HIV Protease Inhibitor Nelfinavir Down-Regulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells

Author:

Kushchayeva Yevgeniya12,Jensen Kirk1,Recupero Antony1,Costello John1,Patel Aneeta1,Klubo-Gwiezdzinska Joanna2,Boyle Lisa3,Burman Kenneth2,Vasko Vasyl1

Affiliation:

1. Department of Pediatrics (K.J., A.R., J.C., A.P., V.V.), Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814

2. Department of Medicine (Y.K., J.K.-G., K.B.), Washington, DC 20010

3. Division of Endocrinology, Washington Hospital Center, and Department of Surgery (L.B.), Medstar Georgetown University Hospital, Washington, DC 20010

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference44 articles.

1. Familial medullary thyroid cancer: clinical aspects and prognosis;Hyer;Eur J Surg Oncol,2005

2. Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer;Cook;Am J Transl Res,2010

3. Targeting the RET pathway in thyroid cancer;Wells;Clin Cancer Res,2009

4. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study;Elisei;J Clin Endocrinol Metab,2008

5. Medullary thyroid carcinoma relapse reversed with dichloroacetate: a case report;Flavin;Oncol Lett,2010

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