A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults

Author:

Yuen Kevin C. J.1,Conway Gerard S.2,Popovic Vera3,Merriam George R.4,Bailey Timothy5,Hamrahian Amir H.6,Biller Beverly M. K.7,Kipnes Mark8,Moore Jerome A.9,Humphriss Eric10,Bright George M.10,Cleland Jeffrey L.10

Affiliation:

1. Endocrinology, Diabetes and Clinical Nutrition (K.C.J.Y.), Oregon Health and Science University, Portland, Oregon 97239

2. Endocrinology (G.S.C.), University College London Hospitals, London NW1 2BU, United Kingdom

3. Faculty of Medicine (V.P.), University of Belgrade and Department of Neuroendocrinology, Clinical Center Serbia, 11000 Belgrade, Serbia

4. VA Puget Sound Health Care System and Metabolism, Endocrinology and Nutrition (G.R.M.), University of Washington School of Medicine, Seattle and Tacoma, Washington 98493

5. AMCR Institute (T.B.), Escondido, California 92026

6. Cleveland Clinic Foundation (A.H.H.), Cleveland, Ohio 44195

7. Neuroendocrine Unit (B.M.K.B.), Massachusetts General Hospital, Boston, Massachusetts 02114

8. Endocrinology, Diabetes & Glandular Disease Clinic (M.K.), San Antonio, Texas 78229

9. Pacific Biodevelopment, LLC (J.A.M.), Emeryville, California 94608

10. Versartis, Inc (E.H., G.M.B., J.L.C.), Redwood City, California 94065

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference38 articles.

1. Compliance and persistence in pediatric and adult patients receiving growth hormone therapy;Rosenfeld;Endocr Pract,2008

2. Patient outcomes in the GHMonitor: the effect of delivery device on compliance and growth;Desrosiers;Pediatr Endocrinol Rev,2005

3. Monitoring of concordance in growth hormone therapy;Kapoor;Arch Dis Child,2008

4. Human growth hormone therapy: poor adherence equals poor growth;Hunter;Arch Dis Child,2000

5. Non-compliance with growth hormone treatment in children is common and impairs linear growth;Cutfield;PLoS One,2011

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