High-SensitivityBRAFMutation Analysis:BRAFV600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary Thyroid Carcinomas

Author:

de Biase Dario1,Cesari Valentina12,Visani Michela2,Casadei Gian Piero3,Cremonini Nadia4,Gandolfi Greta5,Sancisi Valentina5,Ragazzi Moira6,Pession Annalisa2,Ciarrocchi Alessia5,Tallini Giovanni1

Affiliation:

1. Department of Medicine (D.d.B., V.C., G.T.), Anatomic Pathology Unit, Ospedale Bellaria, University of Bologna, 40139 Bologna, Italy

2. Department of Pharmacology and Biotechnology (V.C., M.V., A.P.), University of Bologna, 40100 Bologna, Italy

3. Anatomic Pathology Unit (G.P.C.), 40133 Bologna, Italy

4. Endocrinology Unit (N.C.), Ospedale Maggiore, 40133 Bologna, Italy

5. Molecular Biology Laboratory (G.G., V.S., A.C.), 42123 Reggio Emilia, Italy

6. Anatomic Pathology Unit (M.R.), Istituto di Ricovero e Cura a Carattere Scientifico-Arcispedale Santa Maria Nuova, 42123 Reggio Emilia, Italy

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference28 articles.

1. BRAF mutations in advanced cancers: clinical characteristics and outcomes;El-Osta;PloS One,2011

2. Mutations of the BRAF gene in human cancer;Davies;Nature,2002

3. Inhibition of mutated, activated BRAF in metastatic melanoma;Flaherty;N Engl J Med,2010

4. Thyroid cancer survival in the United States: observational data from 1973 to 2005;Davies;Arch Otolaryngol Head Neck Surg,2010

5. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma;Kimura;Cancer Res,2003

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