α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes-Reference-Cited by-同舟云学术

α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes

Published:2014-08-01 Issue:8 Volume:99 Page:E1418-E1426
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Gottlieb Peter A.¹,Alkanani Aimon K.¹,Michels Aaron W.¹,Lewis Eli C.²,Shapiro Leland³,Dinarello Charles A.⁴,Zipris Danny¹

Affiliation:

1. Barbara Davis Center for Childhood Diabetes (P.A.G., A.K.A., A.W.M., D.Z.)

2. Department of Clinical Biochemistry and Pharmacology (E.C.L.), Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel

3. Department of Medicine (L.S.), Division of Infectious Diseases, Veterans Affairs Medical Center and University of Colorado Denver, Denver, Colorado 80202

4. Division of Infectious Diseases (C.A.D.), University of Colorado Denver, Aurora, Colorado 80045

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/99/8/E1418/9045460/jcem1418.pdf

Reference40 articles.

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2. Coxsackie B4 virus infection of β-cells and natural killer cell insulitis in recent-onset type 1 diabetic patients;Dotta;Proc Natl Acad Sci U S A,2007

3. Virus Infections: Lessons from Pancreas Histology;Dotta;Curr Diab ReP,2010

4. The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes;Richardson;Diabetologia,2009