Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes-Reference-Cited by-同舟云学术

Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes

Published:2012-07-01 Issue:7 Volume:26 Page:1203-1212
ISSN:0888-8809
Container-title:Molecular Endocrinology
language:en
Short-container-title:

Author:

Yang Beatrice T.¹,Dayeh Tasnim A.¹,Volkov Petr A.¹,Kirkpatrick Clare L.²,Malmgren Siri¹,Jing Xingjun¹,Renström Erik¹,Wollheim Claes B.¹²,Nitert Marloes Dekker¹,Ling Charlotte¹

Affiliation:

1. Department of Clinical Sciences (B.T.Y., T.A.D., P.A.V., S.M., X.J., E.R., C.B.W., M.D.N., C.L.), Lund University Diabetes Centre, Scania University Hospital, 205 02 Malmoe, Sweden;

2. Department of Cell Physiology and Metabolism (C.L.K., C.B.W.), University Medical Center, 1211 Geneva 4, Switzerland

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Link

http://academic.oup.com/mend/article-pdf/26/7/1203/8936833/mend1203.pdf

Reference47 articles.

1. PDX-1 and MafA play a crucial role in pancreatic β-cell differentiation and maintenance of mature β-cell function.;Kaneto;Endocr J,2008

2. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.;Dutta;Proc Natl Acad Sci USA,2001

3. Mechanism of PDX-1 protein transduction.;Noguchi;Biochem Biophys Res Commun,2005

4. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.;Stoffers;Nat Genet,1997