TSPYL5 SNPs: Association with Plasma Estradiol Concentrations and Aromatase Expression

Author:

Liu Mohan1,Ingle James N.2,Fridley Brooke L.3,Buzdar Aman U.4,Robson Mark E.5,Kubo Michiaki6,Wang Liewei1,Batzler Anthony3,Jenkins Gregory D.3,Pietrzak Tracy L.7,Carlson Erin E.3,Goetz Matthew P.2,Northfelt Donald W.8,Perez Edith A.9,Williard Clark V.10,Schaid Daniel J.3,Nakamura Yusuke11,Weinshilboum Richard M.1

Affiliation:

1. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (M.L., L.W., R.M.W.), Mayo Clinic, Rochester, Minnesota 55905

2. Department of Oncology (J.N.I., M.P.G.), Mayo Clinic, Rochester, Minnesota 55905

3. Department of Health Sciences Research (B.L.F., A.B., G.D.J., E.E.C., D.J.S.), Mayo Clinic, Rochester, Minnesota 55905;

4. Department of Breast Oncology (A.U.B.), M.D. Anderson Cancer Center, Houston, Texas 77030;

5. Breast Medicine Service (M.E.R), Memorial Sloan Kettering Cancer Center, New York, New York 10021;

6. RIKEN Center for Genomic Medicine (M.K.), Yokohama City, Japan;

7. Research Application Solutions Unit, Information Technology (T.L.P.), Mayo Clinic, Rochester, Minnesota 55905;

8. Division of Hematology/Oncology (D.W.N.), Mayo Clinic, Scottsdale, Arizona 85259;

9. Division of Hematology/Oncology (E.A.P.), Mayo Clinic, Jacksonville, Florida 32224;

10. PharmaNet USA (C.V.W.), Inc., Princeton, New Jersey 08540;

11. Department of Medicine (Y.N.), Chicago University, School of Medicine, Chicago, Illinois 60637

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference32 articles.

1. Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer;Ingle;Cancer Res,2010

2. The origin of postmenopausal oestrogens;Neven;Eur J Cancer,2002

3. Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women;Schuit;Eur J Endocrinol,2005

4. Ovarian and peripheral plasma levels of progestogens, androgens and oestrogens in post-menopausal women;Lucisano;Maturitas,1984

5. Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha;Kinoshita;Cancer Res,2003

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