Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

Author:

Strushkevich Natallia12,Gilep Andrei A.3,Shen Limin1,Arrowsmith Cheryl H.1,Edwards Aled M.1,Usanov Sergey A.3,Park Hee-Won12

Affiliation:

1. Structural Genomics Consortium (N.S., L.S., C.H.A., A.M.E., H.-W.P.), University of Toronto, Toronto, Ontario, Canada M5G 1L7;

2. Department of Pharmacology and Toxicology (N.S., H.-W.P.), University of Toronto, Toronto, Ontario, Canada M5S 1A8

3. Institute of Bioorganic Chemistry National Academy of Sciences of Belarus (A.A.G., S.A.U.), Minsk 220141, Belarus;University of Toronto, Toronto, Ontario, Canada M5S 1A8

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference57 articles.

1. Resistant hypertension.;Fagard;Heart,2012

2. Aldosterone and end-organ damage.;Brown;Curr Opin Nephrol Hypertens,2005

3. Aldosterone and arterial hypertension.;Tomaschitz;Nat Rev Endocrinol,2010

4. Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis.;Hartmann;Eur J Med Chem,2003

5. Aldosterone synthase inhibitors: pharmacological and clinical aspects.;Jansen;Curr Opin Investig Drugs,2009

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