Oral Administration of a Retinoic Acid Receptor Antagonist Reversibly Inhibits Spermatogenesis in Mice

Author:

Chung Sanny S. W.1,Wang Xiangyuan1,Roberts Shelby S.1,Griffey Stephen M.2,Reczek Peter R.3,Wolgemuth Debra J.1456

Affiliation:

1. Department of Genetics and Development (S.S.W.C., X.W., S.S.R., D.J.W.), Department of Obstetrics, Columbia University Medical Center, New York, New York 10032;

2. Comparative Pathology Laboratory (S.M.G.), School of Veterinary Medicine, University Of California Davis, Davis, California 95616;

3. Eva Pharmaceuticals, LLC (P.R.R.), Rochester, New York 14618

4. Gynecology (D.J.W.), Columbia University Medical Center, New York, New York 10032;

5. The Institute of Human Nutrition (D.J.W.), Columbia University Medical Center, New York, New York 10032;

6. The Herbert Irving Comprehensive Cancer Center (D.J.W.), Columbia University Medical Center, New York, New York 10032;

Publisher

The Endocrine Society

Subject

Endocrinology

Reference44 articles.

1. Histology of the lesions produced in the reproductive tract of animals fed a diet deficient in vitamin A alcohol but containing vitamin A acid. I. The male rat.;Howell;J Reprod Fertil,1963

2. Tissue changes following deprivation of fat-soluble A vitamin.;Wolbach;J Exp Med,1925

3. Vitamin A functions in the reproductive organs;Eskild,1994

4. Role of retinoid signaling in the regulation of spermatogenesis.;Chung;Cytogenet Genome Res,2004

5. Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor α.;Wolgemuth;Soc Reprod Fertil Suppl,2007

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