Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement

Author:

Salomon Carlos1ORCID,Das Saumya2ORCID,Erdbrügger Uta3,Kalluri Raghu4,Kiang Lim Sai5ORCID,Olefsky Jerrold M6ORCID,Rice Gregory E7ORCID,Sahoo Susmita8ORCID,Andy Tao W9ORCID,Vader Pieter10ORCID,Wang Qun11ORCID,Weaver Alissa M12

Affiliation:

1. Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, Faculty of Medicine, The University of Queensland , Brisbane , Australia

2. Cardiovascular Research Center of Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA

3. Department of Medicine, Nephrology Division, University of Virginia , Charlottesville, VA , USA

4. Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center , Houston, TX , USA

5. Institute of Molecular and Cell Biology, Agency for Science, Technology and Research , Singapore

6. Department of Medicine, University of California-San Diego , La Jolla, CA , USA

7. Inoviq Limited , Notting Hill, Australia

8. Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai , New York, NY , USA

9. Department of Biochemistry, Purdue University , West Lafayette, IN , USA

10. CDL Research, Division LAB, UMC Utrecht, Utrecht, the Netherlands Faculty of Medicine, Utrecht University, Utrecht, the Netherlands; Laboratory of Experimental Cardiology , UMC Utrecht, Utrecht , The Netherlands

11. Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University , Jinan , China

12. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, TN , USA

Abstract

Abstract During the last decade, there has been great interest in elucidating the biological role of extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell communication. The field of endocrinology is uniquely placed to provide insight into the functions of EVs, which are secreted from all cells into biological fluids and carry endocrine signals to engage in paracellular and distal interactions. EVs are a heterogeneous population of membrane-bound vesicles of varying size, content, and bioactivity. EVs are specifically packaged with signaling molecules, including lipids, proteins, and nucleic acids, and are released via exocytosis into biofluid compartments. EVs regulate the activity of both proximal and distal target cells, including translational activity, metabolism, growth, and development. As such, EVs signaling represents an integral pathway mediating intercellular communication. Moreover, as the content of EVs is cell-type specific, it is a “fingerprint” of the releasing cell and its metabolic status. Recently, changes in the profile of EV and bioactivity have been described in several endocrine-related conditions including diabetes, obesity, cardiovascular diseases, and cancer. The goal of this statement is to highlight relevant aspects of EV research and their potential role in the field of endocrinology.

Publisher

The Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Cited by 58 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3