Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

Author:

Diaz-Vegas Alexis12,Sanchez-Aguilera Pablo1,Krycer James R2,Morales Pablo E1,Monsalves-Alvarez Matías13,Cifuentes Mariana134,Rothermel Beverly A5,Lavandero Sergio154ORCID

Affiliation:

1. Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile

2. Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, Sydney, NSW, Australia

3. Institute of Nutrition and Food Technology (INTA), Universidad de Chile, Santiago, Chile

4. Center for Studies of Exercise, Metabolism and Cancer (CEMC), Facultad de Medicina, Universidad de Chile, Santiago, Chile

5. Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, Texas

Abstract

Abstract Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.

Funder

Agencia Nacional de Investigacion y Desarrollo

American Heart Association

National Institutes of Health

National Health and Medical Research Council

Australian Research Council

Publisher

The Endocrine Society

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

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