Subclinical Hypothyroidism in Korean Preterm Infants Associated with High Levels of Iodine in Breast Milk

Author:

Chung Hye Rim1,Shin Choong Ho2,Yang Sei Won2,Choi Chang Won1,Kim Beyong Il1

Affiliation:

1. Department of Pediatrics (H.R.C., C.W.C., B.I.K.), Seoul National University Bundang Hospital, Seongnam 463-707, Korea

2. Department of Pediatrics (C.H.S., S.W.Y.), Seoul National University Children’s Hospital, Seoul 110-774, Korea

Abstract

Context: The dietary iodine intake of lactating women has been reported to be high in Korea. Objectives: The aim of this study was to assess iodine balance and to determine its relationship with thyroid function in preterm infants. Design: Thyroid functions of preterm infants born at 34 wk gestation or less were evaluated in the first (n = 31) and third (n = 19) weeks. Mothers’ breast milk (BM) and random urine samples of infants were taken on the same days for thyroid function tests. Results: Iodine concentrations in BM were very high (198–8484 μg/liter), and one third of the infants had an iodine intake of more than 100 μg/kg per day at the third week after birth (excessive iodine intake group). At that time, the levels of TSH were positively correlated with urinary iodine (r = 0.622; P = 0.004). The frequencies of subclinical hypothyroidism were high in the excessive iodine intake group at the third and sixth weeks. The estimated daily iodine intake at the third week (51.2 ± 45.5 vs. 149.0 ± 103.8 μg/kg per day; P = 0.033), urinary iodine at the third week (913.2 ± 1179.7 vs. 1651.3 ± 1135.2 μg/liter; P = 0.051), and estimated daily iodine intake at the sixth week (32.8 ± 35.5 vs. 92.1 ± 51.2 μg/kg per day; P = 0.032) were significantly higher in infants with subclinical hypothyroidism than in controls. Conclusions: Excessive iodine intake from BM contributed to subclinical hypothyroidism in these preterm Korean infants. An excessive amount of iodine in breast milk causes subclinical hypothyroidism in preterm infants.

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. Effect of iodide on human choriogonadotropin, sodium-iodide symporter expression and iodide uptake in BeWo choriocarcinoma cells.;Li;J Clin Endocrinol Metab,2007

2. Optimal iodine nutrition during pregnancy, lactation and the neonatal period.;Delange;Int J Endocrinol Metab,2004

3. Neonatal hypothyroxinemia: effects of iodine intake and premature birth.;Ares;J Clin Endocrinol Metab,1997

4. Iodine deficiency associated with parenteral nutrition in extreme preterm infants;Ibrahim;Arch Dis Child Fetal Neonatal Ed,2003

Cited by 69 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3