Thyrotropin Secretion in Mild and Severe Primary Hypothyroidism Is Distinguished by Amplified Burst Mass and Basal Secretion with Increased Spikiness and Approximate Entropy

Author:

Roelfsema Ferdinand1,Pereira Alberto M.1,Adriaanse Ria2,Endert Erik3,Fliers Eric3,Romijn Johannes A.1,Veldhuis Johannes D.4

Affiliation:

1. Department of Endocrinology and Metabolic Diseases (F.R., A.M.P., J.A.R.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

2. Department of Internal Medicine (R.A.), de Tjongerschans, 8441 PW Heerenveen, The Netherlands

3. Department of Endocrinology and Metabolism (E.E., E.F.), Academic Medical Center of the University of Amsterdam, 1100 DE Amsterdam, The Netherlands

4. Endocrine Research Unit (J.D.V.), Mayo Medical and Graduate Schools, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55901

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference44 articles.

1. Mariotti S 2006 Normal physiology of the hypothalamo-pituitary-thyroidal system and relation to the neural system and other endocrine gland. In: De GrootLJ, ed. Thyroid disease manager. Chap 4. www.thyroidmanager.com

2. Neuroendocrine control of thyrotropin secretion;Morley;Endocr Rev,1981

3. Diurnal TSH variations in hypothyroidism;Weeke;J Clin Endocrinol Metab,1976

4. Pathophysiology of pulsatile and copulsatile release of thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and α-subunit;Samuels;J Clin Endocrinol Metab,1990

5. Circadian changes in pulsatile TSH release in primary hypothyroidism;Adriaanse;Clin Endocrinol (Oxf),1992

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