Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis

Author:

Jayasena Channa N.1,Nijher Gurjinder M. K.1,Chaudhri Owais B.1,Murphy Kevin G.1,Ranger Amita1,Lim Adrian2,Patel Daksha2,Mehta Amrish2,Todd Catriona2,Ramachandran Radha1,Salem Victoria1,Stamp Gordon W.3,Donaldson Mandy4,Ghatei Mohammad A.1,Bloom Stephen R.1,Dhillo Waljit S.1

Affiliation:

1. Department of Investigative Medicine (C.N.J., G.M.K.N., O.B.C., K.G.M., A.R., R.R., V.S., M.A.G., S.R.B., W.S.D.), Imperial College London, Hammersmith Hospital, London W12 ONN, United Kingdom

2. Imaging Department (A.L., D.P., A.M., C.T.), Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, United Kingdom

3. Department of Histopathology (G.W.S.), Imperial College London, Hammersmith Hospital, London W12 ONN, United Kingdom

4. Department of Clinical Biochemistry (M.D.), Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, United Kingdom

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference39 articles.

1. Female hypogonadotropic hypogonadism. Hypothalamic amenorrhea syndrome.;Yen;Endocrinol Metab Clin North Am,1993

2. Adult-onset amenorrhea: a study of 262 patients.;Reindollar;Am J Obstet Gynecol,1986

3. Height and weight at menarche and a hypothesis of critical body weights and adolescent events.;Frisch;Science,1970

4. Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea.;Laughlin;J Clin Endocrinol Metab,1998

5. Low energy availability, not stress of exercise, alters LH pulsatility in exercising women.;Loucks;J Appl Physiol,1998

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