Possible Relevance between Prohormone Convertase 2 Expression and Tumor Growth in Human Adrenocorticotropin-Producing Pituitary Adenoma

Author:

Iino Kazumi12,Oki Yutaka1,Yamashita Miho1,Matsushita Fumie1,Hayashi Chiga1,Yogo Kosuke1,Nishizawa Shigeru3,Yamada Shozo4,Maekawa Masato2,Sasano Hironobu5,Nakamura Hirotoshi1

Affiliation:

1. Second Division (K.I., Y.O., M.Y., F.M., C.H., K.Y., H.N.), Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan;

2. Department of Medicine, and Department of Laboratory Medicine (K.I., M.M.), Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan;

3. Department of Neurosurgery (S.N.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan;

4. Department of Hypothalamic and Pituitary Surgery (S.Y.), Endocrine Center, Toranomon Hospital, Tokyo 105-8470, Japan;

5. Department of Pathology (H S.), Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference39 articles.

1. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.;Seidah;Brain Res,1999

2. Biosynthesis of peptide hormones derived from precursor sequences.;Eggelkraut-Gottanka;Curr Med Chem,2004

3. Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas.;Jin;Pituitary,1999

4. Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy.;Takumi;Mod Pathol,1998

5. α-Melanocyte-stimulating hormone is present in the inferior petrosal sinuses in patients with Cushing’s disease.;Colao;Neuroendocrinology,1993

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