A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain

Author:

Nader Nancy1,Bachrach Bert E.2,Hurt Darrell E.3,Gajula Sonia2,Pittman Amy2,Lescher Rachel2,Kino Tomoshige1

Affiliation:

1. Unit on Molecular Hormone Action (N.N., T.K.), Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

2. Department of Pediatric Endocrinology/Diabetes (B.E.B., S.G., A.P., R.L.), University of Missouri Children’s Hospital, Columbia Missouri 65212

3. Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and Bioinformatics and Computational Biosciences Branch (D.E.H.), Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference9 articles.

1. Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder;Charmandari;J Clin Endocrinol Metab,2008

2. Novel causes of generalized glucocorticoid resistance;Charmandari;Horm Metab Res,2007

3. Glucocorticoid and mineralocorticoid receptors and associated diseases;Kino;Essays Biochem,2004

4. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic;Chrousos;Sci STKE,2005

5. Tissue glucocorticoid resistance/hypersensitivity syndromes;Kino;J Steroid Biochem Mol Biol,2003

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