Transforming Growth Factor-β1 Down-Regulation of Major Histocompatibility Complex Class I in Thyrocytes: Coordinate Regulation Of Two Separate Elements by Thyroid-Specific as Well as Ubiquitous Transcription Factors

Author:

Napolitano Giorgio1,Montani Valeria1,Giuliani Cesidio1,Di Vincenzo Simonetta1,Bucci Ines1,Todisco Valentina1,Laglia Giovanna1,Coppa Anna2,Singer Dinah S.3,Nakazato Minoru4,Kohn Leonard D.4,Colletta Giulia5,Monaco Fabrizio1

Affiliation:

1. Chair of Endocrinology (G.N., V.M., C.G., S.D.V., I.B., V.T., G.L., F.M.), Chieti, Italy 66100

2. Department of Experimental Medicine and Pathology (A.C.) University “La Spienza”, Rome, Italy 00161

3. Experimental Immunology Branch (D.S.S.), Bethesda, Maryland 20892-1800

4. National Cancer Institute and Metabolic Diseases Branch (M.N., L.D.K.) National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892-1800

5. Department of Medicine and Department of Oncology and Neuroscience (G.C.) University “G. D’Annunzio”, Chieti, Italy 66100

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference70 articles.

1. Transforming growth factor beta (TGF-β) in inflammation: a cause and a cure.;Wahl;J Clin Immunol,1992

2. TGF-β signal transduction.;Massague,;Annu Rev Biochem,1998

3. Inhibition of interferon-γ-induced major histocompatibility complex class II gene transcription by interferon-β and type β1 transforming growth factor in human astrocytoma cells.;Devajyothi;J Biol Chem,1993

4. Transforming growth factor-β down-regulates major histocompatibility complex Class I antigen expression and increases the susceptibility of uveal melanoma cells to natural killer cell-mediated cytolysis.;Ma;J Immunol,1995

5. Dual effect of transforming growth factor β on rat thyroid cells: inhibition of thyrotropin-induced proliferation and reduction of thyroid-specific differentiation markers.;Colletta;Cancer Res,1989

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