1. Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic E-Institutes of Shanghai Universities, and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Shanghai 200025, Chin