Human Melatonin and Alerting Response to Blue-Enriched Light Depend on a Polymorphism in the Clock Gene PER3

Author:

Chellappa Sarah L.12,Viola Antoine U.1,Schmidt Christina1,Bachmann Valérie3,Gabel Virginie1,Maire Micheline1,Reichert Carolin F.1,Valomon Amandine1,Götz Thomas1,Landolt Hans-Peter3,Cajochen Christian1

Affiliation:

1. Centre for Chronobiology (S.L.C., A.U.V., C.S., V.G., M.M., C.F.R., A.V., T.G., C.C.), Psychiatric Hospital of the University of Basel, CH-4012 Basel, Switzerland

2. The CAPES Foundation/Ministry of Education of Brazil (S.L.C.), CEP 22641-310 Brasilia-DF, Brazil

3. Institute of Pharmacology and Toxicology (V.B., H.-P.L.), University of Zurich, CH-8032 Zurich, Switzerland

Abstract

Context: Light exposure, particularly at the short-wavelength range, triggers several nonvisual responses in humans. However, the extent to which the melatonin-suppressing and alerting effect of light differs among individuals remains unknown. Objective: Here we investigated whether blue-enriched polychromatic light impacts differentially on melatonin and subjective and objective alertness in healthy participants genotyped for the PERIOD3 (PER3) variable-number, tandem-repeat polymorphism. Design, Setting, and Participants: Eighteen healthy young men homozygous for the PER3 polymorphism (PER35/5and PER34/4) underwent a balanced crossover design during the winter season, with light exposure to compact fluorescent lamps of 40 lux at 6500 K and at 2500 K during 2 h in the evening. Results: In comparison to light at 2500 K, blue-enriched light at 6500 K induced a significant suppression of the evening rise in endogenous melatonin levels in PER35/5 individuals but not in PER34/4. Likewise, PER35/5 individuals exhibited a more pronounced alerting response to light at 6500 K than PER34/4 volunteers. Waking electroencephalographic activity in the theta range (5–7 Hz), a putative correlate of sleepiness, was drastically attenuated during light exposure at 6500 K in PER35/5 individuals as compared with PER34/4. Conclusions: We provide first evidence that humans homozygous for the PER3 5/5 allele are particularly sensitive to blue-enriched light, as indexed by the suppression of endogenous melatonin and waking theta activity. Light sensitivity in humans may be modulated by a clock gene polymorphism implicated in the sleep-wake regulation.

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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