Comparative Effects of Variations in Duodenal Glucose Load on Glycemic, Insulinemic, and Incretin Responses in Healthy Young and Older Subjects

Author:

Trahair Laurence G.12,Horowitz Michael12,Rayner Christopher K.12,Gentilcore Diana13,Lange Kylie12,Wishart Judith M.12,Jones Karen L.12

Affiliation:

1. University of Adelaide (L.G.T., M.H., C.K.R., D.G., K.L., J.M.W., K.L.J.), Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia 5000

2. National Health and Medical Research Council Centre of Clinical Research Excellence in Nutritional Physiology, Interventions, and Outcomes (L.G.T., M.H., C.K.R., K.L., J.M.W., K.L.J.), Adelaide, Australia 5000

3. University of South Australia (D.G.), School of Health Sciences, Adelaide, Australia 5000

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994.;Harris;Diabetes Care,1998

2. Impaired β-cell function in human aging: response to nicotinic acid-induced insulin resistance.;Chang;J Clin Endocrinol Metab,2006

3. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals.;Meneilly;J Clin Endocrinol Metab,1997

4. Effect of aging and diabetes on the enteroinsular axis.;Korosi;J Gerontol A Biol Sci Med Sci,2001

5. Effect of aging on glucose homeostasis: accelerated deterioration of β-cell function in individuals with impaired glucose tolerance.;Szoke;Diabetes Care,2008

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