Serum Sclerostin and Risk of Hip Fracture in Older Caucasian Women

Author:

Arasu Aarthi1,Cawthon Peggy M.23,Lui Li-Yung23,Do Thy P.4,Arora Puneet S.4,Cauley Jane A.5,Ensrud Kristine E.6,Cummings Steven R.2,

Affiliation:

1. Department of Medicine (A.A.), California, 94107

2. University of California, San Francisco, and San Francisco Coordinating Center (P.M.C., L.-Y.L., S.R.C.), California, 94107

3. California Pacific Medical Center Research Institute (P.M.C, L.-Y.L., S.R.C.), San Francisco, California, 94107

4. Amgen Inc., (T.P.D., P.S.A.) Thousand Oaks, California 91320

5. Department of Epidemiology (J.A.C.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

6. Minneapolis Veterans Affairs Medical Center (K.E.E.), University of Minnesota, Minneapolis, Minnesota 55417

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. An estimate of the worldwide prevalence, mortality and disability associated with hip fracture.;Johnell;Osteoporos Int,2004

2. Nonresponders to osteoporosis therapy.;Lewiecki;J Clin Densitom,2003

3. Risk of fracture among women who lose bone density during treatment with alendronate. The Fracture Intervention Trial.;Chapurlat;Osteoporos Int,2005

4. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.;Li;J Biol Chem,2005

5. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.;Semënov;J Biol Chem,2005

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