Mineralocorticoid Receptor Mutations Differentially Affect Individual Gene Expression Profiles in Pseudohypoaldosteronism Type 1

Author:

Fernandes-Rosa Fábio L.123,Hubert Edwige-Ludiwyne23,Fagart Jérome45,Tchitchek Nicolas6,Gomes Debora1,Jouanno Elodie37,Benecke Arndt6,Rafestin-Oblin Marie-Edith89,Jeunemaitre Xavier237,Antonini Sonir R.1,Zennaro Maria-Christina237

Affiliation:

1. Department of Puericulture and Pediatrics (F.L.F.-R., D.G., S.R.A.), School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-900, Brazil;

2. Institut National de la Santé et de la Recherche Médicale, Unité 970 (F.L.F.-R., E.-L.H., X.J., M.-C.Z.), Paris Cardiovascular Research Center-PARCC, 75015 Paris, France;

3. University Paris Descartes (F.L.F.-R., E.-L.H., E.J., X.J., M.-C.Z.), 75005 Paris, France;

4. Institut National de la Santé et de la Recherche Médicale, Unité 693 (J.F.), 94275 Le Kremlin Bicêtre, France;

5. University Paris-Sud (J.F.), 94270 Le Kremlin-Bicêtre, France;

6. Institut des Hautes Études Scientifiques (N.T., A.B.), 91440 Bures sur Yvette, France;

7. Assistance Publique-Hôpitaux de Paris (E.J., X.J., M.-C.Z.), Hôpital Européen Georges Pompidou, 75015 Paris France;

8. Institut National de la Santé et de la Recherche Médicale, Unité 773 (M.-E.R.-O.), Centre de Recherche Biomédicale Bichat-Beaujon CRB3, 75870 Paris, France;

9. University Paris Diderot (M.-E.R.-O.), 75475 Paris, France

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms.;Verrey;Kidney Int,2000

2. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.;Viengchareun;Nucl Recept Signal,2007

3. Interdomain interactions in the mineralocorticoid receptor.;Rogerson;Mol Cell Endocrinol,2003

4. Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface.;Liu;Mol Endocrinol,1996

5. Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.;Fagart;Nat Struct Mol Biol,2005

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