Insulin- and Leptin-Mediated Control of Aquaglyceroporins in Human Adipocytes and Hepatocytes Is Mediated via the PI3K/Akt/mTOR Signaling Cascade

Author:

Rodríguez Amaia12,Catalán Victoria12,Gómez-Ambrosi Javier12,García-Navarro Socorro32,Rotellar Fernando42,Valentí Víctor4,Silva Camilo52,Gil María J.62,Salvador Javier52,Burrell María A.7,Calamita Giuseppe8,Malagón María M.32,Frühbeck Gema52

Affiliation:

1. Metabolic Research Laboratory (A.R., V.C., J.G.-A., G.F.) University of Navarra, 31080 Pamplona, Spain;

2. Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (A.R., V.C., J.G.-A., S.G.-N., F.R., C.S., M.J.G., J.S., M.M.M., G.F.), Instituto de Salud Carlos III, 28029 Madrid, Spain

3. Department of Cell Biology, Physiology, and Immunology (S.G.-N., M.M.M.), University of Córdoba, 14001 Córdoba, Spain;

4. Departments of Surgery (F.R., V.V.), Clínica Universidad de Navarra, 31008 Pamplona, Spain;

5. Departments of Endocrinology (C.S., J.S., G.F.), Clínica Universidad de Navarra, 31008 Pamplona, Spain;

6. Departments of Biochemistry (M.J.G.), Clínica Universidad de Navarra, 31008 Pamplona, Spain;

7. Department of Histology and Pathology (M.A.B.), University of Navarra, 31080 Pamplona, Spain;

8. Department of General and Environmental Physiology (G.C.), University of Bari Aldo Moro, 70126 Bari, Italy;

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference54 articles.

1. From structure to disease: the evolving tale of aquaporin biology.;King;Nat Rev Mol Cell Biol,2004

2. Obesity: aquaporin enters the picture.;Frühbeck;Nature,2005

3. Aquaporins and their metabolic implications.;Rodríguez;Obes Metab,2007

4. Glyceroneogenesis and the triglyceride/fatty acid cycle.;Reshef;J Biol Chem,2003

5. Aquaporin adipose, a putative glycerol channel in adipocytes.;Kishida;J Biol Chem,2000

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