Lower Brain-Derived Neurotrophic Factor in Patients with Prader-Willi Syndrome Compared to Obese and Lean Control Subjects

Author:

Han Joan C.1,Muehlbauer Michael J.2,Cui Huaxia N.2,Newgard Christopher B.2,Haqq Andrea M.3

Affiliation:

1. Unit on Growth and Obesity (J.C.H.), Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892;

2. Sarah W. Stedman Nutrition and Metabolism Center (M.J.M., H.N.C., C.B.N.), Duke University Medical Center, Durham, North Carolina 27705;

3. Division of Pediatric Endocrinology (A.M.H.), Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2J3

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. Elevated plasma ghrelin levels in Prader Willi syndrome.;Cummings;Nat Med,2002

2. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.;Haqq;J Clin Endocrinol Metab,2003

3. Increased leptin messenger RNA and serum leptin levels in children with Prader-Willi syndrome and nonsyndromal obesity.;Lindgren;Pediatr Res,1997

4. Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects.;Goldstone;J Clin Endocrinol Metab,2002

5. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.;Xu;Nat Neurosci,2003

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