Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans
Author:
Ouellet Veronique1, Routhier-Labadie Annick1, Bellemare William1, Lakhal-Chaieb Lajmi2, Turcotte Eric3, Carpentier André C.4, Richard Denis1
Affiliation:
1. Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec and Merck Frosst/Canadian Institutes for Health Research Research Chair in Obesity (V.O., A.R.-L., W.B., D.R.), Faculty of Medicine, Université Laval, Québec, Québec, Canada G1V 4G5 2. Department of Mathematics and Statistics (L.L.-C.), Université Laval, Québec, Québec, Canada G1V 0A6 3. Sherbrooke Molecular Imaging Center (E.T.), Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5N4 4. Department of Medicine (A.C.C.), Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5N4
Abstract
Context: In humans, the prevalence, mass, and glucose-uptake activity of 18F-fluorodeoxyglucose (18F-FDG)-detected brown adipose tissue (BAT), which are expectedly enhanced by a cold stimulus, also appear modulated by other factors that still have to be disentangled.
Objective: The objective of the study was to investigate the factors determining the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans.
Research Design and Methods: We retrospectively analyzed all 18F-FDG positron emission tomography/computed tomography examinations performed between January 2007 and December 2008 at our institution for 18F-FDG uptake within the cervical/supraclavicular, mediastinal, paravertebral, and perirenal fat areas. The influence of outdoor temperature, sex, age, body mass index (BMI), plasma glucose level, diabetes diagnosis, day length, and cancer status on the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT depots was investigated.
Results: Three hundred twenty-eight of the 4842 patients (6.8%) had 18F-FDG-detected BAT. The prevalence of 18F-FDG BAT was negatively associated with outdoor temperature (P < 0.0001), age (P < 0.0001), BMI (P < 0.0001), and diabetes status (P = 0.0003). Moreover, there was a significant age × sex interaction for the prevalence of 18F-FDG BAT (the younger the subjects, the greater the sex difference). The mass and glucose-uptake activity of 18F-FDG-detected BAT also decreased with increasing outdoor temperature (P < 0.0001), age (P < 0.0001), and BMI (P < 0.0001). They were lower in men than in women (P < 0.001) and lower in diabetic than in nondiabetic patients (P = 0.0002).
Conclusions: The present study identifies outdoor temperature, age, sex, BMI, and diabetes status as determinants of the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT.
Publisher
The Endocrine Society
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism
Cited by
452 articles.
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