Adrenocortical Tumorigenesis in Transgenic Mice Expressing the Inhibin α-Subunit Promoter/Simian Virus 40 T-Antigen Transgene: Relationship between Ectopic Expression of Luteinizing Hormone Receptor and Transcription Factor GATA-4

Author:

Rahman Nafis A.1,Kiiveri Sanne2,Rivero-Müller Adolfo1,Levallet Jérôme1,Vierre Susanna1,Kero Jukka1,Wilson David B.34,Heikinheimo Markku23,Huhtaniemi Ilpo15

Affiliation:

1. Department of Physiology (N.A.R., A.R.-M., J.L., S.V., J.K., I.H.), University of Turku, 20520 Turku, Finland

2. Program for Developmental and Reproductive Biology, Biomedicum Helsinki and Children’s Hospital (S.K., M.H.), University of Helsinki, 00029 Helsinki, Finland

3. Departments of Pediatrics (D.B.W., M.H.), St. Louis, Missouri 63110

4. Pharmacology (D.B.W.), Washington University, St. Louis, Missouri 63110

5. Institute of Reproductive and Developmental Biology (I.H.), Imperial College London, Faculty of Medicine, London W12 0NN, United Kingdom

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference53 articles.

1. Adrenocortical carcinoma.;Schulick;World J Urol,1999

2. Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin α-subunit gene.;Kananen;Mol Endocrinol,1996

3. Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin α-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines.;Kananen;Mol Endocrinol,1995

4. The mouse inhibin α-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice.;Kananen;Mol Cell Endocrinol,1996

5. Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin α-subunit promoter/simian virus 40 T-antigen fusion gene.;Rilianawati Paukku;Mol Endocrinol,1998

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