Affiliation:
1. Department of Internal Medicine, Berufsgenossenschaftliche Kliniken Bergmannsheil, University of Bochum, D-44789 Bochum, Germany
Abstract
Abstract
There is now a large body of evidence suggesting that the decline in ovarian function with menopause is associated with spontaneous increases in proinflammatory cytokines. The cytokines that have obtained the most attention are IL-1, IL-6, and TNF-α. The exact mechanisms by which estrogen interferes with cytokine activity are still incompletely known but may potentially include interactions of the ER with other transcription factors, modulation of nitric oxide activity, antioxidative effects, plasma membrane actions, and changes in immune cell function. Experimental and clinical studies strongly support a link between the increased state of proinflammatory cytokine activity and postmenopausal bone loss. Preliminary evidence suggests that these changes also might be relevant to vascular homeostasis and the development of atherosclerosis. Better knowledge of the mechanisms and the time course of these interactions may open new avenues for the prevention and treatment of some of the most prevalent and important disorders in postmenopausal women.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Reference507 articles.
1. Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women.;Burger;J Clin Endocrinol Metab,1999
2. The crippling consequences of fractures and their impact on quality of life.;Cooper;Am J Med,1997
3. Women and heart disease;Maxwell;Basic Res Cardiol,1998
4. The vascular protective effects of estrogen.;Farhat;FASEB J,1996
5. The protective effects of estrogen on the cardiovascular system.;Mendelsohn;N Engl J Med,1999
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