Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

Author:

Liu Xiaomeng123,Wang Siping4,You Yilin5,Meng Minghui1,Zheng Zongji6,Dong Meng12,Lin Jun12,Zhao Qianwei12,Zhang Chuanhai7,Yuan Xiaoxue12,Hu Tao12,Liu Lieqin1,Huang Yuanyuan1,Zhang Lei1,Wang Dehua8,Zhan Jicheng5,Jong Lee Hyuek1,Speakman John R.910,Jin Wanzhu1

Affiliation:

1. Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.), Chinese Academy of Sciences, Beijing 100101, China

2. The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China

3. College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China

4. Department of Special Service (S.W.), Chinese PLA General Hospital, Tsinghua, Haidian District, Beijing 100083, China

5. College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China

6. Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China

7. College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China

8. State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

9. State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

10. Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom

Publisher

The Endocrine Society

Subject

Endocrinology

Reference30 articles.

1. Cellular bioenergetics as a target for obesity therapy;Tseng;Nat Rev Drug Discov,2010

2. Transcriptional control of brown adipocyte development and physiological function—of mice and men;Seale;Genes Dev,2009

3. Transplantation of adipose tissue and stem cells: role in metabolism and disease;Tran;Nat Rev Endocrinol,2010

4. Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues;Walden;Am J Physiol Endocrinol Metab,2012

5. Comparison of hormone-sensitive lipase activity visceral and subcutaneous human adipose tissue;Reynisdottir;J Clin Endocrinol Metab,1997

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