1. University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre (L.R.P., J.M.K., E.H., E.G.B., S.G., S.Sa., S.O., I.B., I.S.F.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ United Kingdom
2. Graduate Program in Cellular and Molecular Biology (R.J., C.C.-S.), Harvard University, Boston, Massachusetts 02115
3. Department of Molecular and Integrative Physiology (M.E.D., H.-W.S., L.S.A., J.M.C., L.R., C.C.-S.), Harvard University, Boston, Massachusetts 02115
4. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109–5622; Joslin Diabetes Center and Department of Medicine (S.Sh.), Harvard University, Boston, Massachusetts 02115
5. Wellcome Trust Sanger Institute (I.B.), Hinxton, CB10 1SA United Kingdom
6. Division of Metabolism, Endocrinology, and Diabetes (C.C.-S.), Harvard University, Boston, Massachusetts 02115