Functional Maturation of the Primate Fetal Adrenal in Vivo: 3. Specific Zonal Localization and Developmental Regulation of CYP21A2 (P450c21) and CYP11B1/CYP11B2 (P450c11/Aldosterone Synthase) Lead to Integrated Concept of Zonal and Temporal Steroid Biosynthesis**Presented in part, at the 79th Annual Meeting of The Endocrine Society, Minneapolis, Minnesota, June 1997. Supported, in part, by NIH Grant HD-08478 and a block grant from the National Health and Medical Research Council of Australia.

Author:

Coulter Catherine L.1,Jaffe Robert B.1

Affiliation:

1. Reproductive Endocrinology Center, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143-0556

Publisher

The Endocrine Society

Subject

Endocrinology

Reference26 articles.

1. Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17α-hydroxylase/17,20-lyase, and 3β-hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of functional zonation.;Mesiano;J Clin Endocrinol Metab,1993

2. Functional maturation of the primate fetal adrenal in vivo: 2. Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3β-hydroxysteroid dehydrogenase/isomerase (3βHSD).;Coulter;Endocrinology,1996

3. Developmental and functional biology of the primate fetal adrenal cortex.;Mesiano;Endocr Rev,1997

4. Programmed cell death in remodelling of the human fetal adrenal cortex: possible role of activin-A.;Spencer,1995

5. Immunohistochemical evaluation of the cellular localization and ontogeny of 3 β-hydroxysteroid dehydrogenase/delta 5–4 isomerase in the human fetal adrenal gland.;Parker Jr;Endocr Res,1995

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