EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β*

Author:

Tremblay André1,Tremblay Gilles B.1,Labrie Claude2,Labrie Fernand2,Giguère Vincent13

Affiliation:

1. Molecular Oncology Group, Royal Victoria Hospital (A.T., G.B.T., V.G.), Montreal, Québec, Canada H3A 1A1

2. Laboratory of Molecular Endocrinology, CHUL Research Center (C.L., F.L.), Québec City, Québec, Canada G1V 4G2

3. Departments of Biochemistry, Medicine, and Oncology, McGill University (V.G.), Montreal, Québec, Canada H3A 1A1

Publisher

The Endocrine Society

Subject

Endocrinology

Reference43 articles.

1. Development of antiestrogens and thier use in breast cancer: Eighth Cain Memorial Award Lecture.;Lerner;Cancer Res,1990

2. Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers.;Fornander;Lancet,1989

3. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase.;Kato;Science,1995

4. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.;Bunone;EMBO J,1996

5. Cloning, chromosomal localization and functional analysis of the murine estrogen receptor β.;Tremblay;Mol Endocrinol,1997

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