Dexamethasone Impairs Growth Hormone (GH)-Stimulated Growth by Suppression of Local Insulin-Like Growth Factor (IGF)-I Production and Expression of GH- and IGF-I-Receptor in Cultured Rat Chondrocytes*

Author:

Jux Christian1,Leiber Kathrin1,Hügel Ulrike1,Blum Werner2,Ohlsson Claes3,Klaus Günter4,Mehls Otto1

Affiliation:

1. From the Departments of Pediatrics (C.J., K.L., U.H., O.M.), D-35033, Germany

2. University Children’s Hospitals, Heidelberg, D-69120 Giessen (W.B.), D-35033, Germany

3. Research Center of Endocrinology and Metabolism (C.O.), Sahlgrenska Hospital, University of Göteborg, Sweden S-41345

4. D-35392, Marburg (G.K.), D-35033, Germany

Publisher

The Endocrine Society

Subject

Endocrinology

Reference56 articles.

1. Effects of prolonged cortisone therapy on the statual growth, skeletal maturation and metabolic status of children.;Blodgett;N Engl J Med,1956

2. Glucocorticoids and growth. In: Kelnar CJH (ed) Baillière’s Clinical Paediatrics - International Practice and Research.;Tönshoff;WB Saunders, London,,1996

3. Growth hormone prevents steroid-induced growth depression in health and uremia.;Kovacs;Kidney Int,1991

4. Glucocorticoids: potent inhibitors and stimulators of growth hormone secretion.;Wehrenberg;Endocrinology,1990

5. Steroid regulation of growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids in the rat.;Gabrielsson;Endocrinology,1995

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