Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa

Author:

Morelli Annamaria1,Filippi Sandra1,Mancina Rosa1,Luconi Michaela1,Vignozzi Linda1,Marini Mirca2,Orlando Claudio3,Vannelli Gabriella Barbara2,Aversa Antonio4,Natali Alessandro5,Forti Gianni1,Giorgi Mauro6,Jannini Emmanuele A.6,Ledda Fabrizio7,Maggi Mario1

Affiliation:

1. Andrology Unit (A.M., S.F., R.M., M.L., L.V., G.F., Ma.M.), University of Florence, Florence 50139, Italy

2. Department of Anatomy, Histology and Forensic Medicine (Mi.M., G.B.V.), University of Florence, Florence 50139, Italy

3. Clinical Biochemistry (C.O.)Department of Clinical Physiopathology, , University of Florence, Florence 50139, Italy

4. Chair of Internal Medicine III (A.A.), Department of Physiopathology, University of Rome “La Sapienza,” Rome 00100, Italy

5. Department of Urology (A.N.), University of Florence, Florence 50139, Italy

6. Department of Experimental Medicine (M.G., E.A.J.), University of L’Aquila, 67100 L’Aquila, Italy

7. Department of Pharmacology (F.L.), University of Florence, Florence 50139, Italy

Publisher

The Endocrine Society

Subject

Endocrinology

Reference47 articles.

1. Cyclic nucleotide phosphodiesterases: relating structure and function.;Francis;Prog Nucleic Acid Res Mol Biol,2001

2. Therapeutic potential of selective PDE inhibitors in asthma.;Schudt;Pulm Pharmacol Ther,1999

3. β-Adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate.;Movsesian;J Am Coll Cardiol,1999

4. Phosphodiesterases as therapeutic targets.;Lin;Urology,2003

5. Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized.;Manganiello;Mol Pharmacol,2003

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