Genomic Structure and Characterization of the 5′-Flanking Region of the Human Ghrelin Gene

Author:

Kanamoto Naotetsu1,Akamizu Takashi12,Tagami Tetsuya3,Hataya Yuji1,Moriyama Kenji1,Takaya Kazuhiko2,Hosoda Hiroshi24,Kojima Masayasu45,Kangawa Kenji24,Nakao Kazuwa1

Affiliation:

1. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (N.K., T.A., Y.H., K.M., K.N.), Kyoto 606-8507, Japan

2. Ghrelin Research Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine (T.A., K.T., H.H., K.K.), Kyoto 606-8507, Japan

3. Clinical Research Institute, Center for Endocrine and Metabolic Diseases, Kyoto National Hospital (T.T.), Kyoto 612-8555, Japan

4. Department of Biochemistry, National Cardiovascular Center Research Institute (H.H., M.K., K.K.), Osaka 565-8565, Japan

5. Institute of Life Science, Kurume University (M.K.), Fukuoka 839-0861, Japan

Publisher

The Endocrine Society

Subject

Endocrinology

Reference71 articles.

1. Getting to the guts of enteroendocrine differentiation.;Skipper;Nat Genet,2000

2. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.;Kojima;Nature,1999

3. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.;Date;Endocrinology,2000

4. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors.;Korbonits;J Clin Endocrinol Metab,2001

5. Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion.;Date;Diabetes,2002

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