1. Heart and Stroke Richard Lewar Center of Excellence (R.G., X.Y., M.G.K., A.M.S., I.N.M., T.G.P., M.H.), University of Toronto;
2. Division of Cellular and Molecular Biology (R.G., X.Y., M.G.K., A.M.S., I.N.M., T.G.P., M.H.), Toronto General Hospital Research Institute;
3. Department of Medicine, Banting and Best Diabetes Centre (L.L.B., Q.H., D.J.D.), Toronto General Hospital, University of Toronto, Toronto, Canada M5G 2C4