The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics

Author:

Ceraudo Emilie1,Murail Samuel2,Tan Yossan-Var1,Lacapère Jean-Jacques1,Neumann Jean-Michel2,Couvineau Alain1,Laburthe Marc1

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale Unité 773 (E.C., Y.-V.T., J.-J.L, A.C., M.L.), Centre de Recherche Biomédicale Bichat-Beaujon, CRB3, Faculté de Médecine Xavier Bichat, 75018 Paris, France

2. Commissariat a l’Energie Atomique Division des Sciences du Vivant/Département de Biologie Joliot Curie (S.M., J.-M.N.), Unité de Recherche Associé Centre National de la Recherche Scientifique 2096, Centre d’Etudes de Saclay, 91191 Gif sur Yvette Cedex, France

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference32 articles.

1. The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily.;Sherwood;Endocr Rev,2000

2. The significance of vasoactive intestinal peptide in immunomodulation.;Delgado;Pharmacol Rev,2004

3. VIP, PACAP and related peptides: from gene to therapy.;Vaudry;Ann NY Acad Sci,2006

4. VIP-PACAP system in immunity: new insights for multitarget therapy.;Gomariz;Ann NY Acad Sci,2006

5. Pharmaceutical VIP: prospects and problems.;Fridkinb;Curr Med Chem,1999

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