Calcium/Calmodulin Kinase Inhibitors and Immunosuppressant Macrolides Rapamycin and FK506 Inhibit Progestin- and Glucocorticosteroid Receptor-Mediated Transcription in Human Breast Cancer T47D Cells

Author:

Le Bihan Stéphane1,Marsaud Véronique2,Mercier-Bodard Christine3,Baulieu Etienne-Emile1,Mader Sylvie4,White John H.5,Renoir Jack-Michel2

Affiliation:

1. INSERM U33 (S.L.B., E.-E.B.), France

2. URA 1218 Centre Nationale de la Recherche Scientifique (V.M., J.-M.R.) Pharmacologie Cellulaire 92296 Chatenay-Malabry Cédex, France

3. IFR 21 (C.M.-B.) 94276 Le Kremlin-Bicêtre Cedex, France

4. Department of Biochemistry (S.M.) Faculty of Medicine University of Montreal Montréal, Québec, H3TIJ4, Canada

5. Departments of Physiology and Medicine (J.H.W.) McGill University Montréal, Quebec, H361Y6 Canada

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference78 articles.

1. Steroid receptor interactions with heat shock protein and immunophilin chaperones.;Pratt;Endocr Rev,1997

2. Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones.;Joab;Nature,1984

3. The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.;Catelli;EMBO J,1985

4. Evidence that heat shock protein-70 associated with progesterone receptors is not involved in receptor-DNA binding.;Onate;Mol Endocrinol,1991

5. Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both Hsp70 and Hsp 90.;Sanchez;J Biol Chem,1990

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