Dominant Negative Regulation by c-Jun of Transcription of the Uncoupling Protein-1 Gene through a Proximal cAMP-Regulatory Element: A Mechanism for Repressing Basal and Norepinephrine-Induced Expression of the Gene before Brown Adipocyte Differentiation

Author:

Yubero Pilar1,Barberá MaJosé1,Alvarez Rosa1,Viñas Octavi1,Mampel Teresa1,Iglesias Roser1,Villarroya Francesc1,Giralt Marta1

Affiliation:

1. Departament de Bioquímica i Biologia Molecular Universitat de Barcelona 08028-Barcelona, Spain

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference59 articles.

1. The bioenergetic mechanisms of brown adipose tissue mitochondria.;Nicholls;Brown Adipose Tissue.,1986

2. Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue.;Ricquier;J Biol Chem,1986

3. Tissue-specific and beta-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5′-flanking region.;Cassard-Doulcier;Mol Endocrinol,1993

4. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.;Kozak;Mol Cell Biol,1994

5. CCAAT/enhancer binding proteins alpha and beta are transcriptional activators of the brown fat uncoupling protein gene promoter.;Yubero;Biochem Biophys Res Commun,1994

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