Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline

Author:

LeRoith Derek1ORCID,Biessels Geert Jan2,Braithwaite Susan S34,Casanueva Felipe F5,Draznin Boris6,Halter Jeffrey B78,Hirsch Irl B9,McDonnell Marie E10,Molitch Mark E11,Murad M Hassan12,Sinclair Alan J13

Affiliation:

1. Icahn School of Medicine at Mount Sinai, New York, New York

2. University Medical Center Utrecht, Utrecht, Netherlands

3. Presence Saint Francis Hospital, Evanston, Illinois

4. Presence Saint Joseph Hospital, Chicago, Illinois

5. Complejo Hospitalario Universitario de Santiago, CIBER de Fisiopatologia Obesidad y Nutricion, Instituto Salud Carlos III, Santiago de Compostela, Spain

6. University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado

7. University of Michigan, Ann Arbor, Michigan

8. National University of Singapore, Singapore, Singapore

9. University of Washington Medical Center–Roosevelt, Seattle, Washington

10. Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

11. Northwestern University Feinberg School of Medicine, Chicago, Illinois

12. Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota

13. King’s College, London, United Kingdom

Abstract

Abstract Objective The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more prevalent in the general population, especially in individuals over the age of 65 years. The underlying pathophysiology of the disease in these patients is exacerbated by the direct effects of aging on metabolic regulation. Similarly, aging effects interact with diabetes to accelerate the progression of many common diabetes complications. Each section in this guideline covers all aspects of the etiology and available evidence, primarily from controlled trials, on therapeutic options and outcomes in this population. The goal is to give guidance to practicing health care providers that will benefit patients with diabetes (both type 1 and type 2), paying particular attention to avoiding unnecessary and/or harmful adverse effects.

Funder

National Institutes of Health

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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