Affiliation:
1. Developmental Endocrinology Branch, National Institute of Child Health and Human Development (M.A., V.K.B., C.A.B.), Bethesda, Maryland 20892
2. Warren G. Magnuson Clinical Center Radiology Department (S.H.), National Institutes of Health, Bethesda, Maryland 20892
Abstract
Abstract
Background: Many girls with Turner syndrome (TS) are treated with GH to increase adult height. In addition to promoting longitudinal bone growth, GH has effects on bone and body composition.
Objective: The objective was to determine how GH treatment affects bone mineral density (BMD) and body composition in girls with TS.
Method: In a cross-sectional study, we compared measures of body composition and BMD by dual energy x-ray absorptiometry, and phalangeal cortical thickness by hand radiography in 28 girls with TS who had never received GH and 39 girls who were treated with GH for at least 1 yr. All girls were participants in a National Institutes of Health (NIH) Clinical Research Center (CRC) protocol between 2001 and 2006.
Results: The two groups were similar in age (12.3 yr, sd 2.9), bone age (11.5 yr, sd 2.6), and weight (42.8 kg, sd 16.6); but the GH-treated group was taller (134 vs. 137 cm, P = 0.001). The average duration of GH treatment was 4.2 (sd 3.2) yr (range 1–14 yr). After adjustment for size and bone age, there were no significant differences in BMD at L1–L4, 1/3 radius or cortical bone thickness measured at the second metacarpal. However, lean body mass percent was higher (P < 0.001), whereas body fat percent was lower (P < 0.001) in the GH-treated group. These effects were independent of estrogen exposure and were still apparent in girls that had finished GH treatment at least 1 yr previously.
Conclusions: Although GH treatment has little effect on cortical or trabecular BMD in girls with TS, it is associated with increased lean body mass and reduced adiposity.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference20 articles.
1. Sex chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark;Nielsen;Birth Defects Orig Artic Ser,1990
2. Growth failure in early life: an important manifestation of Turner syndrome;Davenport;Horm Res,2002
3. Impact of growth hormone supplementation on adult height in Turner syndrome: results of the Canadian randomized controlled trial;J Clin Endocrinol Metab,2005
4. Bone mineral density assessed by phalangeal radiographic absorptiometry before and during long-term growth hormone treatment in girls with Turner’s syndrome participating in a randomized dose-response study;Sas;Pediatr Res,2001
5. Turner syndrome adolescents receiving growth hormone are not osteopenic;Neely;J Clin Endocrinol Metab,1993
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