Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women-Reference-Cited by-同舟云学术

Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women

Published:2007-01-01 Issue:1 Volume:92 Page:255-263
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Cust Anne E.¹²³,Kaaks Rudolf¹⁴,Friedenreich Christine⁵,Bonnet Fabrice⁶⁷,Laville Martine⁶⁷,Lukanova Annekatrin⁸,Rinaldi Sabina¹,Dossus Laure¹,Slimani Nadia¹,Lundin Eva⁹,Tjønneland Anne¹⁰,Olsen Anja¹⁰,Overvad Kim¹¹,Clavel-Chapelon Françoise¹²,Mesrine Sylvie¹²,Joulin Virginie¹²,Linseisen Jakob⁴,Rohrmann Sabine⁴,Pischon Tobias¹³,Boeing Heiner¹³,Trichopoulos Dimitrios¹⁴,Trichopoulou Antonia¹⁴,Benetou Vassiliki¹⁴,Palli Domenico¹⁵,Berrino Franco¹⁶,Tumino Rosario¹⁷,Sacerdote Carlotta¹⁸,Mattiello Amalia¹⁹,Quirós J. Ramón²⁰,Mendez Michelle A.²¹,Sánchez María-José²²,Larrañaga Nerea²³,Tormo M. J.²⁴,Ardanaz Eva²⁵,Bueno-de-Mesquita H. Bas²⁶,Peeters Petra H. M.²⁷,van Gils Carla H.²⁷,Khaw Kay-Tee²⁸,Bingham Sheila²⁹³⁰,Allen Naomi³¹,Key Tim³¹,Jenab Mazda¹,Riboli Elio³²

Affiliation:

1. Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France

2. School of Public Health (A.E.C.), University of Sydney, Sydney 2006, Australia

3. Université Claude Bernard Lyon 1 (A.E.C.), 69622 Lyon, France

4. German Cancer Research Center (R.K., J.L., S.Ro.), 69120 Heidelberg, Germany

5. Division of Population Health and Information (C.F.), Alberta Cancer Board, Calgary, Alberta, Canada T2N 4N2

6. Center for Research in Human Nutrition Rhône-Alpes (F.Bo., M.L.), University of Lyon 1, 69622 Lyon, France

7. Unité Mixte de Recherche, Institut National de la Santé et de la Recherche Médicale U449/Institut National de la Recherche Agronomique 1235 (F.Bo., M.L.), Lyon, France

8. Department of Obstetrics and Gynecology (A.L.), New York University School of Medicine, New York, New York 10016

9. Department of Pathology (E.L.), Umeå University, SE-901 87 Umeå, Sweden

10. Institute of Cancer Epidemiology (A.Tj., A.O.), Danish Cancer Society, DK-2100 Copenhagen, Denmark

11. Department of Clinical Epidemiology (K.O.), Aarhus University Hospital, DK-8000 C Aalborg, Denmark

12. Institut National de la Santé et de la Recherche Médicale (F.C.-C., S.M., V.J.), Institut Gustave Roussy, 94805 Villejuif, France

13. German Institute of Human Nutrition (T.P., H.B.), Potsdam-Rehbrücke, 14558 Nuthetal, Germany

14. University of Athens Medical School (D.T., A.Tr., V.B.), Athens 11527, Greece

15. Department of Molecular and Nutritional Epidemiology (D.P.), CSPO-Scientific Institute of Tuscany, 50135 Florence, Italy

16. Epidemiology Unit (F.Be.), Istituto Nazionale Tumori, 20133 Milan, Italy

17. Cancer Registry (R.T.), Azienda Ospedaliera “Civile M.P. Arezzo,” 98158 Ragusa, Italy

18. CPO-Piemonte (C.S.), 10126 Torino, Italy

19. Dipartimento di Medicina Clinica e Sperimentale (A.M.), Federico II University of Naples, 80131 Naples, Italy

20. Public Health and Health Planning Directorate (J.R.Q.), Asturias, Spain

21. Institut d’Investigació Biomèdica de Bellvitge (M.A.M.), Catalan Institute of Oncology, 08907 Barcelona, Spain

22. Andalusian School of Public Health (M.-J.S.), Granada, Spain

23. Public Health Department of Gipuzkoa (N.L.), Basque Government

24. Epidemiology Department (M.J.T.), Health Council of Murcia, 30008 Murcia, Spain

25. Public Health Institute of Navarra (E.A.), Pamplona, Spain

26. National Institute of Public Health and the Environment (H.B.B.-d.M.), 3720 BA Bilthoven, The Netherlands

27. Julius Center for Health Sciences and Primary Care (P.H.M.P., C.H.v.G.), University Medical Center, 3508 CX Utrecht, The Netherlands

28. Clinical Gerontology (K.-T.K.), Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, United Kingdom

29. Medical Research Council Centre for Nutritional Epidemiology in Cancer Prevention and Survival (S.B.), Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 1TN, United Kingdom

30. Medical Research Council Dunn Human Nutrition Unit (S.B.), Cambridge CB2 2XY, United Kingdom

31. Cancer Research U.K. Epidemiology Unit (N.A., T.K.), University of Oxford, Oxford OX3 7LF, United Kingdom

32. Department of Epidemiology and Public Health (E.R.), Imperial College London, London SW7 2AZ, United Kingdom

Abstract

Abstract Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer. Methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition to examine the relation between prediagnostic plasma adiponectin levels and endometrial cancer risk. Among pre- and postmenopausal women who were not currently using exogenous hormones, 284 women developed incident endometrial cancer during an average of 5.1 yr of follow-up. Using risk set sampling, 548 control subjects were selected, matched on center, age, menopausal status, phase of menstrual cycle, time of blood draw, and fasting status. Conditional logistic regression models were used to estimate relative risks and 95% confidence intervals. Results: Adiponectin levels were inversely associated with endometrial cancer risk [body mass index-adjusted relative risk for the top vs. bottom quartile = 0.56 (95% confidence interval 0.36–0.86), Ptrend = 0.006]. There was evidence of a stronger inverse association among obese women than among nonobese women (Pheterogeneity = 0.03). The inverse association also appeared stronger for women who were postmenopausal or perimenopausal than premenopausal at baseline, but this was not statistically significantly heterogeneous (Pheterogeneity = 0.51). The association remained statistically significant after separate adjustment for other obesity-related physiological risk factors such as C-peptide, IGF binding protein-1, IGF binding protein-2, SHBG, estrone, or free testosterone but only marginally statistically significant after simultaneous adjustment for these factors. Conclusions: High circulating adiponectin levels are associated with reduced endometrial cancer risk, largely independent of other obesity-related risk factors.

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/92/1/255/11059506/jcem0255.pdf

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