Protein Synthesis Inhibitors, in Synergy with 5-Azacytidine, Restore Sodium/Iodide Symporter Gene Expression in Human Thyroid Adenoma Cell Line, KAK-1, SuggestingTrans-Active Transcriptional Repressor

Author:

Li Wei1,Venkataraman Gopalakrishnan M.1,Ain Kenneth B.1

Affiliation:

1. Thyroid Cancer Research Laboratory, Medical Service, Veterans Affairs Medical Center, Lexington, Kentucky 40511; and the Thyroid Oncology Program, Division of Hematology/Oncology, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536-0093

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference38 articles.

1. Thyroid cancer: a lethal neoplasm.;Robbins;Ann Intern Med,1991

2. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism.;Pohlenz;Biochimie (Paris),1999

3. Failure of membrane targeting causes the functional defect of two mutant sodium iodide symporters.;Pohlenz;J Clin Endocrinol Metab,2000

4. Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation status.;Venkataraman;J Clin Endocrinol Metab,1999

5. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.;Santi;Proc Natl Acad Sci USA,1984

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